By Gerardo R. Vasta PhD, Hafiz Ahmed PhD
Introduces Groundbreaking techniques for Assessing Lectin Function
Lectins and their ligands are lower than particularly a heavy microscope as a result of their capability functions to pharmacology, immunology, melanoma treatment, and agriculture. With becoming curiosity within the glycobiology box, the physique of study regarding lectin roles has grown at an explosive expense, rather long ago twenty years. Animal Lectins: A practical View provides the main updated research of those carbohydrate-binding, and possibly lifesaving, proteins in a single accomplished quantity.
This standard-setting source provides new insights into the organic roles of such a lot animal lectins, together with their functionality in an infection prevention via innate immunity. It additionally discusses such lectin behaviors as:
- Glycoprotein folding
- Sorting and targeting
- Cell adhesion
- Cell-cell interactions and signaling
Describes the Structural foundation of Protein-Carbohydrate Interactions
Under the editorial advice of 2 best protein chemistry specialists and with contributions from well-recognized box gurus, this e-book logically and systematically discusses either intracellular and extracellular lectin capabilities. it really is a vital springboard for destiny box study and a transparent and concise wisdom base that glycobiology, biochemistry, and immunology researchers can't find the money for to be without.
Read Online or Download Animal Lectins: A Functional View PDF
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Additional resources for Animal Lectins: A Functional View
The authors provide solid evidence to claim that galectins can serve as immunosuppressive agents or targets for anti-inflammatory drugs. Stowell and Cummings (Chapter 28) evaluate the effects of galectins on leukocytes in aspects of innate immunity. The authors propose that galectins may serve as key immune regulatory elements, which can induce key changes in leukocytes, including apoptotic death, removal and turnover, or immunosuppressive alterations in cytokine production. Galectins are believed to play a key role to signal leukocyte elimination or shift toward a more tolerable Th2 outcome, following their release during excessive immune-mediated tissue damage.
Laevis) or C-type domains (D. melanogaster). indd 24 9/6/2008 2:23:31 PM Structural Aspects of Lectin–Ligand Interactions 25 AAA is a physiological trimer (Kelly, 1984). Although the crystal structure of AAA shows a protomer per asymmetric unit, the crystal belongs to a space group (R32) that includes a threefold symmetry. This fact and the area buried by the trimer generated by application of the threefold suggest that the trimer present in the crystal is physiological. Since the function of lectins is to bind surface glycans in a multivalent fashion, the proposed trimer of the AAA–fucose complex provides the basis for understanding the function of this protein in innate immunity.
1998), most of which have been implicated in cell adhesion or developmental processes (Vogel, 1999). , 1981). Thus, it is plausible that carbohydrate recognition is the ancestral function of this domain, which may have evolved into a phospholipid-binding domain, as in the case of the coagulation factors V and VIII. ) Sequence alignment of selected F-lectins. Fully conserved residues are shown on a magenta background; partially conserved residues are shown in red and cysteine residues are shown in green.
Animal Lectins: A Functional View by Gerardo R. Vasta PhD, Hafiz Ahmed PhD