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More recently, a study found that the keratinization was similar on the internal and external portions of the foreskin (Dinh et al. 2010). B. The subpreputial space acts as a breeding ground for sexually transmitted viruses. This is usually supported by the spurious claims that HSV-2 and HPV are more common in normal men. C. Langerhans cells in the lining of the foreskin facilitate the transfer of HIV into the body. Such a claim has several problems. a. The Langerhans cells are quite good at keeping HIV out of the body.

Two subsequent studies of HSV-2 likewise found no difference (Dickson et al. 2005; Xu et al. 2007). Initially the investigators of the three RCTs reported no difference in risk of HSV-2 seroconversion (Auvert et al. 2007); however, later one of the RCTs found men in the control group to be at greater risk for HSV-2 seroconversion (Tobian et al. 2009) and another found a non-statistically significant trend (Sobngwi-Tambekou et al. 2009). When the data are adjusted for the built-in lead time bias in both studies, the differences are not statistically significant (Storms 2009).

AIDS Alert 2007; 22: 25–28. 2 Routine Infant Circumcision 39 5. The data from the RCTs have limited scope because of the short duration of the trials. The CPs have taken this short-term data and extrapolated them over several decades to estimate the savings in lives and dollars (Williams et al. 2006; Nagelkerke et al. 2007; Londish and Murray 2008; Podder et al. 2007; Kahn et al. 2006). These models make four assumptions that have no factual basis. a. The results in a research setting from motivated, well-compensated volunteers can be duplicated in the real world.

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A Trip in Time to the Year 2000 and Beyond

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